ECE: Electrical & Computer Engineering
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Bioinformatics Seminar: Systems Biology and Next Generation Sequencing Approaches to Studying Complex Disease

12:00 AM - 10:30 AM on Friday, October 26, 2012
Location: Virginia Tech Research Center -Arlington, Room 4-024

Invited Speaker: Dr./Prof. Zhongming Zhao, Department of Biomedical Informatics at Vanderbilt University

Genome-wide association studies (GWAS) have become a popular approach to search for common genetic variants with susceptibility to complex diseases or traits. Recently, pathway- or network-based analysis of GWAS datasets has emerged as an alternative but potentially powerful search approach for disease causal genes, assuming a complex disease may have resulted from a number of genes that disrupt one or more pathways or protein complexes. This talk covers our recently developed dense module search of genetic signals from GWAS dataset(s) in protein-protein interaction network. In the second part, I will present some next generation sequencing projects, aiming to uncover disease-related genes or markers, and their underlying molecular mechanisms.